Birc6 protein folding

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August undefined, 2024

WebBIRC6. TISSUE CELL TYPE TISSUES. ADIPOSE SUBCUTANEOUS ADIPOSE VISCERAL BREAST COLON HEART MUSCLE KIDNEY LIVER LUNG. PANCREAS PROSTATE SKELETAL MUSCLE SKIN STOMACH TESTIS THYROID. Cell type enrichment. ... The Human Protein Atlas project is funded by the Knut & Alice Wallenberg Foundation. ... WebBIRC6. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC.

BIRC6 protein expression summary - The Human Protein Atlas

WebBIRC6. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. … WebSep 27, 2024 · In addition, CHX chase assays showed that HECTD1 overexpression accelerated BIRC6 protein degradation (Figure 3D), whereas BIRC6 protein was more stable after HECTD1 knockdown (Figure 3E). To further investigate whether degradation of BIRC6 was mediated through ubiquitination, we cotransfected 293T cells with Myc … birmingham method hip replacement

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WebFeb 9, 2024 · The enormous protein BIRC6 plays an important role in preventing programmed cell death – earning BIRC6 the nickname "Guardian of the Cell". Scientists from the lab of Tim Clausen now showed that BIRC6’s structure holds the key for regulating cell death, but also for cell survival pathways. Their findings are published in the journal … WebA lentivirus-mediated silencing method was used to knockdown BIRC6, and the biological con-sequences of BIRC6 silencing in three hepatoma cell lines were investigated in vitro and in vivo. We found that BIRC6 overexpres-sion was significantly correlated with serum ALT level and HCC vascular invasion. Patients with positive BIRC6 expression in tumor WebFeb 10, 2024 · Abstract. Background: Baculoviral IAP repeat containing 6 (BIRC6), a member of the inhibitors of apoptosis protein (IAP) family, has been reported to be correlated with oncogenesis. The aim of this study was to investigate the prognostic significance of BIRC6 in prostate cancer, as well as its effects on prostate cancer cell lines. birmingham methodist district

BIRC6 baculoviral IAP repeat containing 6 [ (human)]

Expression of BIRC6 in cancer - Summary - The Human Protein …

WebHeat shock protein 47, also known as SERPINH1 is a serpin which serves as a human chaperone protein for collagen. Function. This protein is a member of the serpin superfamily of serine proteinase inhibitors. Its expression is induced by heat shock. HSP47 is expressed in the endoplasmic reticulum. WebFeb 9, 2024 · BIRC6 adopts a dimeric, horseshoe-shaped architecture with a central cavity that allows for binding to target proteases. The pro-apoptotic protein SMAC binds very … dange chowk pune pin codeWebBIRC6 is part of cluster 45 Non-specific - Cell proliferation with confidence i ... RAN binding protein 2: 0.4987: 45: SNRNP200: Small nuclear ribonucleoprotein U5 subunit 200: 0.4809: 45: PSME4: Proteasome activator subunit 4: 0.4785: 45: VPS13C: Vacuolar protein sorting 13 homolog C: 0.4776: 45: ZNF638: danged chimichanga

"WebThe BIRC6 protein is at 528 kDa, an unusually large member of the IAP family. It consists of a single N-terminal BIR domain and a C-terminal ubiquitin-conjugating (UBC) domain; the latter " - Birc6 protein folding

Birc6 protein folding

Identification of BIRC6 as a novel intervention target for ... - PubMed

WebElevated BIRC6 protein expression may serve as a predictive marker for chemoresistance of NSCLCs and a poor prognostic factor for NSCLC patients. … This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.

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WebFeb 8, 2013 · Background BIRC6 is a member of the Inhibitors of Apoptosis Protein (IAP) family which is thought to protect a variety of cancer cells from apoptosis. The main objective of the present study was to investigate …

Webralph lauren mens shoes sale; harmony collection clothing; MON-SAT 10:00AM - 7:00PM PST WebJul 18, 2024 · A conserved ORF was identified in the circBIRC6-2 sequence that had the potential to encode a protein of 236 aa; we named this putative protein BIRC6-236aa (Fig. 4A). To encode a protein, a cRNA must …

WebMar 14, 2024 · BIRC6 is a large protein (528 kDa) with pleiotropic functions, including inhibition of apoptosis, cytoprotection and regulation of cytokinesis , and mitosis . Its activity is upregulated in many cancers, including prostate cancer, particularly CRPC ( 9 ), associated with poor patient prognosis ( 10–14 ), and shown to enhance … WebThis gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein …

WebOriginal Article Overexpression of BIRC6 driven by EGF-JNK-HECTD1 signaling is a potential therapeutic target for triple-negative breast cancer Yongpeng Li,1 ,2 10Yanan Tan,34 Lijuan Wen,5 Zhihao Xing,6 Changxu Wang,7 Liuhui Zhang,8 Kai Wu,1 Haiyan Sun, 1Yuqing Li, Qifang Lei,1 and Song Wu ,9 1The Third Afﬁliated Hospital of Shenzhen …

WebThus, the reciprocal inhibition between BIRC6 and caspase activation is a potential mecha-nism by which cells may coordinate survival and apoptotic processes [20,43,45,46]. BIRC6 has been shown to be important in cell cycle progression and DNA damage repair where it functions as a scaffold protein for assembly of the DNA damage repair machinery dangee corporationWebBIRC6. Status. UniProtKB reviewed (Swiss-Prot) Organism. Homo sapiens (Human) Amino acids. 4857. Protein existence. Evidence at protein level. Annotation score. 5/5. Entry. … dange brownWebMar 21, 2024 · Complete information for BIRC6-AS1 gene (RNA Gene), BIRC6 Antisense RNA 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium ... BIRC6 Antisense RNA 1 (Non-Protein Coding) (HGNC, NCBI Entrez Gene) NONHSAG027421.2 ; HSALNG0146433 ; BIRC6 … birmingham mesothelioma caseWebMar 21, 2024 · BIRC6 baculoviral IAP repeat containing 6 [ (human)] Gene ID: 57448, updated on 5-Feb-2024. Summary. This gene encodes a protein with a BIR (baculoviral … dangee share price nseWebFeb 10, 2024 · Baculoviral IAP repeat containing protein 6 (BIRC6) is one of the apoptosis inhibitor proteins contributing to cancer cells' survival in many cancer types with diagnostic and treatment importance. birmingham methodist district directoryWebDec 2, 2024 · Inhibitors of apoptosis proteins (IAPs) have been associated with tumor development and progression by affecting apoptosis through cell death signaling pathways. To date, eight IAPs (BIRC1–8) have been identified in mammalian cells. However, the role of IAPs in non–small cell lung cancer (NSCLC) development and progression has not … dangeers of eating cerealWebAbstract. Background: BIRC6 is a member of the Inhibitors of Apoptosis Protein (IAP) family which is thought to protect a variety of cancer cells from apoptosis. The main objective of … dan geherin attorney