WebJul 20, 2015 · A shift to short-chain glycans is an observed change in mucin-type O-glycosylation in premalignant and malignant epithelia. Given the evidence that human galectin-3 can interact with mucins and also weakly with free tumor-associated Thomsen-Friedenreich (TF) antigen (CD176), the study of its interaction with MUC1 (glyco)peptides … WebApr 15, 2015 · In this study, we developed a method for the fast production of α2,6-sialylated IgG1 by transient co-expression of human GT, ST6 and IgG1 in CHO cells. The mAbs used as models were the humanized trastuzumab (TZM) IgG1 antibody possessing a human Fc, and its F243A mutated version. The effect of co-expressing GT, ST6, or both on …
Insights into the role of sialylation in cancer progression and ...
WebThe carbohydrate-deficient glycoprotein syndromes (CDGS) are genetic, multisystemic diseases characterized by deficiencies in the glycosylation of many secretory glycoproteins, lysosomal enzymes, and possibly cell surface glycoproteins resulting in central nervous system abnormalities and frequent early death by infection. Here we examined whether … WebRecognizes a disaccharide epitope, Gal1-3GalNAc, of Thomsen-Friedenreich (TF) antigen. It is specific for both anomeric forms of the disaccharide (TF and TF, including related structures on the glycolipid) and shows no cross-reactivity with sialylated glycophorin. The Thomsen-Friedenreich antigen acts as an oncofetal antigen, with low expression in … smallpox through time
CD176 / T-F Ag Monoclonal Mouse Antibody (A68-B/A11)
WebApr 6, 2024 · Several sialylated mucosal pathogens have been previously demonstrated to alter human immune cell signaling pathways by directly engaging siglec receptors,,,. This technology labels sialylated glycans with a specifically reactive, abiotic, azide functional group. In contrast, the human alveolus, a representative deep lung tissue, has been shown ... WebNov 4, 2024 · The highly sialylated cell-surface protein CD24, which is overexpressed in some forms of ovarian and breast cancer, binds to Siglec-10 on macrophages, thereby protecting the tumour cells from ... WebSep 4, 2014 · Alternatively, highly sialylated (anti-inflammatory) Abs may eliminate undesirable Ab-induced inflammatory reactions in tumor tissue that may promote tumor … smallpox to natives