Cisplatin gdf15
WebJan 15, 2015 · Introduction Chemotherapy-related endothelial damage contributes to the early development of cardiovascular morbidity in testicular cancer patients. We aimed to identify relevant mechanisms of and search for candidate biomarkers for this endothelial damage. Methods Human micro-vascular endothelial cells (HMEC-1) were exposed to … WebAug 15, 2024 · Cisplatin increases circulating growth differentiation factor 15 (GDF-15), a cytokine that induces conditioned taste aversion, anorexia and weight loss in preclinical models. GDF-15 signals through the hindbrain receptor glial cell-derived neurotrophic factor receptor alpha-like (GFRAL).
Cisplatin gdf15
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WebApr 5, 2024 · The growth differentiation factor 15 (GDF15)/GDNF family receptor alpha-like (GFRAL)/rearranged during transfection (RET) axis is a critical signalling pathway in chemotherapy-induced cachexia. ... A11 inhibited the action of cisplatin-induced GDF15 on the brainstem and decreased GFRAL-positive neuron population expressing c-Fos in the … WebOct 19, 2024 · Growth differentiation factor 15 (GDF15) expression was demonstrated to be controlled by p53 in both ovarian cancer cell lines and orthotopic mouse models. ... In addition, we showed that GDF15 expression can impact the response of both the tumor and stromal cells to cisplatin. GDF15-KD tumors had less stromal component than did …
WebAug 11, 2024 · Growth differentiation factor 15 (GDF15) is a member of the TGFβ superfamily whose expression is increased in response to cellular stress and disease as … WebDec 1, 2024 · GDF15 is one of the major secreted proteins induced by the tumor suppressor protein p53, which acts as a growth inhibitory molecule in tumor cells. This effect is associated with the prosurvival protein activating transcription factor 3, which is negatively regulated by p53 protein expression [15].
WebApr 19, 2024 · Moreover, macrophages from these mice are deficient in release of the secretory factor growth differentiation factor 15 (GDF15), which is required for oxidative metabolism in M2-like macrophages ... Weband growth differentiation factor 15 (GDF15) are involved in the progression of PC. However, the role of Twist and GDF15 in PC remains to be elucidated. In the present study, the individual effect of and interaction between Twist and GDF15 in PC cell invasion and chemoresistance to cisplatin was examined. Twist and /or GDF15 were stably ...
WebFeb 1, 2024 · GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance Cell (2024) N. Lomeli et al. Cisplatin-induced mitochondrial dysfunction is associated with impaired cognitive function in rats Free Radic. Biol. Med. (2024) L.N. Lawton et al. Identification of a novel member of the TGF-beta superfamily highly expressed in human …
WebFeb 17, 2006 · Kemph et al found that expression of GDF15 is induced rapidly in cardiomyocytes on ischemia/reperfusion (I/R) via the nitric oxide-peroxynitrite-dependent signaling pathway. 8 GDF15 is also upregulated … color pack blooketWebApr 5, 2024 · GDF15 is a stress-related cytokine that is released from various tissues, such as the placenta, liver, kidneys, and prostate. 15 Under physiological conditions, the blood … color out of space common sense mediaWebJul 29, 2024 · The cancer-therapeutic drug, cisplatin, induces the release of GDF15 and activates GFRAL AP/NTS neurons, as well as causing … colorpack distributionWebNov 26, 2024 · Influence of growth differentiation factor 15 (GDF15) expression on oral squamous cell carcinoma cell sensitivity to docetaxel, cisplatin, and 5-fluorouracil treatment in vitro. Increased sensitivity (decreased cell viability) was observed in GDF15-overexpressing HB96 and HN6 cells when treated with a series of concentrations of … dr. stephen kwan cardiologyWebSep 15, 2024 · Growth differentiation factor 15 (GDF15) expression was increased in cisplatin- or hypoxia-treated HCC cells. Treatment-induced GDF15 increase in HCC cells was mediated by p38MAPK, JNK, ERK1/2 activation. GDF15 from treatment-damaged HCC cells enhanced the proliferation and collagen synthesis of HSCs through ERK1/2- and … dr stephen lazar new windsorWebFeb 16, 2024 · 50 to 70 mg/m2 by slow IV infusion once every 3 to 4 weeks; for heavily pretreated patients, an initial dose of 50 mg/m2 by slow IV infusion once every 4 weeks … dr. stephen krashen language learningWebNov 7, 2014 · GDF15 Based TPF Induction Chemotherapy for OSCC Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. dr stephen lee ophthalmologist