p16 (also known as p16 , cyclin-dependent kinase inhibitor 2A, CDKN2A, multiple tumor suppressor 1 and numerous other synonyms), is a protein that slows cell division by slowing the progression of the cell cycle from the G1 phase to the S phase, thereby acting as a tumor suppressor. It is encoded by the CDKN2A gene. A deletion (the omission of a part of the DNA sequence during … Webp16 (INK4a/CDKN2A) is a cell cycle regulatory protein that is overexpressed in cervical dysplasia related to human papilloma virus (HPV) infection. Nuclear and cytoplasmic …
p16 - Wikipedia
WebFeb 7, 2011 · Currently, p16 Ink4a is considered a tumor suppressor protein because of its physiological role and downregulated expression in a large number of tumors. Intriguingly, … WebP16-INK4A is a cyclin-dependent kinase inhibitor, which is overexpressed in cell lines where the HPV-induced E7 oncogenic protein product has inactivated the retinoblastoma protein … in the corner of the room stands a jukebox
p16 INK4A Antibody Cell Signaling Technology
WebAug 9, 2010 · Although heterozygous germline mutations of p16INK4a are associated with familial melanoma, most melanomas result from somatic genetic events: often p16 INK4a loss and N-RAS or B-RAF mutational... We demonstrated elevated p16Ink4a protein and acquired senescence feature in activated Slug-deficient SCs. At this point, a key question was whether p16Ink4a is causally involved in Slug loss-induced defects in SC self-renewing capacity and muscle regeneration. To answer this question, we assessed … See more The transcription factor Slug is expressed in a variety of normal tissues in the adult mouse13, indicating its important roles in development. In agreement with this notion, Slug knockout … See more Skeletal muscle regeneration is a highly coordinated process involving the activation of various cellular and molecular responses15. We first decided to examine the … See more To explore intrinsic factors responsible for losing self-renewal capacity of activated SCs in Slug-deficient mice, we initially retrieved and interrogated the global gene expression data (GEO … See more Maintaining SC pool size is crucial for constant muscle turnover/injuries and ongoing repair16. We showed that muscle regeneration after … See more WebMar 26, 2008 · Expression of the tumor suppressor p16 INK4a increases during aging and replicative senescence. Methodology/Principal Findings Here, we report that the microRNA miR-24 suppresses p16 expression in human diploid … new home spring hill