WebFeb 20, 2001 · Peroxisome proliferator-activated receptor α (PPARα) is a nuclear target for fatty acids, hypolipidemic drugs, and other peroxisome proliferators ( 1 – 4) and initiates … WebPeroxisome proliferator-activated receptor-α (PPARα) is a nuclear hormone receptor which regulates the oxidation and transport of fatty acids. Upon activation it binds as a heterodimer with retinoid X receptor (RXR) to peroxisome response elements in genes involved in fatty acid oxidation.
Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic ...
WebPeroxisome proliferator-activated receptor-α (PPARα) is a nuclear hormone receptor which regulates the oxidation and transport of fatty acids. Upon activation it binds as a … WebOct 13, 2003 · Peroxisome proliferator–activated receptor-α (PPAR-α) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily. PPAR-α increases gene … sun cloud grand cayman
Activation of Peroxisome Proliferator–Activated Receptor-α …
WebApr 8, 2024 · Peroxisome proliferator-activated receptor-α (PPARα) and peroxisome proliferator-activated receptor-γ co-activator 1α (PGC1α) primary antibodies were obtained from Abcam (Cambridge, MA, USA, cat nos.: ab126285 and ab54481, respectively). Peroxisome proliferator-activated receptor alpha (PPAR-α), also known as NR1C1 (nuclear receptor subfamily 1, group C, member 1), is a nuclear receptor protein functioning as a transcription factor that in humans is encoded by the PPARA gene. Together with peroxisome proliferator-activated receptor delta … See more PPAR-α is primarily activated through ligand binding. Endogenous ligands include fatty acids such as arachidonic acid as well as other polyunsaturated fatty acids and various fatty acid-derived compounds such as … See more Expression of PPAR-α is highest in tissues that oxidize fatty acids at a rapid rate. In rodents, highest mRNA expression levels of PPAR-alpha are found in liver and brown adipose tissue, followed by heart and kidney. Lower PPAR-alpha expression levels are found in … See more PPAR-α is the pharmaceutical target of fibrates, a class of drugs used in the treatment of dyslipidemia. Fibrates effectively lower serum triglycerides and raises serum HDL-cholesterol levels. Although clinical benefits of fibrate treatment have been … See more PPAR-α has been shown to interact with: • AIP, • EP300 • HSP90AA1, • NCOA1, and • NCOR1. See more PPAR-α is a transcription factor regulated by free fatty acids, and is a major regulator of lipid metabolism in the liver. PPAR-alpha is activated under conditions of energy deprivation … See more Studies using mice lacking functional PPAR-alpha indicate that PPAR-α is essential for induction of peroxisome proliferation by a diverse set of synthetic compounds referred to as peroxisome proliferators. Mice lacking PPAR-alpha also have an … See more PPAR-α governs biological processes by altering the expression of a large number of target genes. Accordingly, the functional role of PPAR-alpha is directly related to the … See more WebThe peroxisome proliferator-activated receptor: A family of nuclear receptors role in various diseases J Adv Pharm Technol Res. 2011 Oct;2 (4):236-40. doi: 10.4103/2231 … sun clock in films