Webb15 mars 2012 · SUMO (small ubiquitin-related modifier) conjugation is a reversible three-step process of protein post-translational modifications mediating protein-protein interactions, subcellular compartmentalization and regulation of transcriptional events. Among divergent transcription factors regulated by SUMOylation and deSUMOylation, … Webb8 apr. 2024 · The ELANE or PPE’s cancer-selective property is dependent on the elevated histone H1 isoforms but not the rare homogeneously expressed and tumor-restricted antigens, a property that raises the ...
Abstract P216: IK-930 mediated TEAD inhibition decreases and …
Webb4 feb. 2024 · In a variety of cancer cell lines, YAP, TAZ and TEAD are found to colocalise with AP-1 to regulatory elements of the genome and are necessary for AP-1-mediated … Webb21 jan. 2016 · Table 1. Summary of TEAD family expression in malignancies. In nearly all the cancer types, the expression of TEADs are up-regulated, suggesting a tumor-promoting role of TEADs. In gastric, colorectal, breast and prostate cancer, the upregulation of TEADs correlates with poor survival in patients. middleboro lakeville herring commission
A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling …
Webb2 dec. 2024 · Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive soft tissue sarcoma with a lack of effective treatment options and a poor prognosis. DSRCT is characterized by a chromosomal translocation, resulting in the EWSR1-WT1 gene fusion. The molecular mechanisms driving DSRCT are poorly understood, and a paucity of … Webb17 juni 2024 · TEAD deregulation affects well-established cancer genes such as KRAS, BRAF, LKB1, NF2, and MYC, and its transcriptional output plays an important role in … Webb21 jan. 2016 · TEAD proteins are required for the participation of coactivators to transmit the signal of pathways for the downstream signaling processes. TEADs also play an … new song new mi